「神药」二甲双胍或导致孩子们生殖器出生缺陷！研究首次揭示父亲使用药物对后代健康的影响

酷海洛

概述：

1. 2. 3. 4. Bednar F, Simeone DM. Metformin and cancer stem cells: old drug, new targets. Cancer Prev Res (Phila). 2012;5:351-4. [PMID: 22389436] doi:10.1158/1940-6207. CAPR-12-00265. Romero R, Erez O, Hüttemann M, et al. Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity. Am J Obstet Gynecol. 2017;217:282-302. [PMID: 28619690] doi:10.1016/j. ajog.2017.06.0036. Ghasemnejad-Berenji M, Ghazi-Khansari M, Yazdani I, et al. Effect of metformin on germ cell-specific apoptosis, oxidative stress and epididymal sperm quality after testicular torsion/detorsion in rats. Andrologia. 2018;50. [PMID: 28730645] doi:10.1111/and. 128467. Tartarin P, Moison D, Guibert E, et al. Metformin exposure affects human and mouse fetal testicular cells. Hum Reprod. 2012;27:3304-14. [PMID: 22811314] doi:10.1093/humrep/des264（可上下滑动详细信息）。

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